| 產(chǎn)品編號 | bs-8537R-RBITC |
| 英文名稱 | Rabbit Anti-Thymidylate synthase/RBITC Conjugated antibody |
| 中文名稱 | 羅丹明（RBITC）標(biāo)記的胸苷酸合成酶抗體 |
| 別 名 | d TMP synthase; EC 2.1.1.45; HsT422; MGC88736; Thymidylate synthase; thymidylate synthetase; TMS; TS; TSase; TYMS; TYMS protein; Tyms thymidylate synthetase; TYSY_HUMAN . |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Thymidylate synthase/TS |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Thymidylate synthase (TS) is an intracellular enzyme critical for de novo synthesis of DNA. In cancer, expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time. Function: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Subunit: Homodimer. Subcellular Location: Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane. Similarity: Belongs to the thymidylate synthase family. Database links: UniProtKB/Swiss-Prot: P04818.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胸苷酸合成酶(thymidylate synthase,TS)是生物體內(nèi)催化胸苷酸合成所必需的酶,多年來一直作為腫瘤化療的重要靶酶。對TS基因調(diào)控機(jī)制的研究表明:基因擴(kuò)增、轉(zhuǎn)錄、翻譯和翻譯后過程都參與了TS表達(dá)的調(diào)控。TS可與自身的mRNA結(jié)合形成TS-mRNA復(fù)合物,使mRNA翻譯受阻,5-氟尿嘧啶(5-fluorouracil,5-FU)等抗代謝藥物可與TS蛋白結(jié)合,結(jié)合后的復(fù)合物不能與TS mRNA作用,導(dǎo)致體內(nèi)TS的表達(dá)升高,是腫瘤細(xì)胞產(chǎn)生抗藥性的重要分子機(jī)制之一。 |
