| 產(chǎn)品編號 | bs-14098R |
| 英文名稱 | CTDSP1 Rabbit pAb |
| 中文名稱 | 羧基端小結(jié)構(gòu)域磷酸酶1抗體 |
| 別 名 | NIF3; NLI-IF; NLIIF; SCP1; GIP; CTDS1_HUMAN; CTDSP1; Nuclear LIM interactor-interacting factor 3 (NLI-IF | NLI-interacting factor 3); Small C-terminal domain phosphatase 1 (SCP1 | Small CTD phosphatase 1); 3.1.3.16; CTDS1_MOUSE; Golli-interacting protein |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 29 kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CTDSP1: 161-261/261 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Subcellular Location: Nucleus. Colocalizes with RNA polymerase II. Tissue Specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. Similarity: Contains 1 FCP1 homology domain. SWISS: Q9GZU7 Gene ID: 58190 Database links: Entrez Gene: 58190 Human Entrez Gene: 227292 Mouse Omim: 605323 Human SwissProt: Q9GZU7 Human SwissProt: P58466 Mouse Unigene: 444468 Human Unigene: 165042 Mouse |
